Millions of data points from four unique research initiatives

Millions of data points from four unique research initiatives

SPARC IBD

SPARC IBD – Study of a Prospective Adult Research Cohort with IBD – is a multicentered longitudinal study of adult IBD patients, which will collect and link clinical data, patient-reported outcome data, and serial biosamples through the course of the patients' disease. Data and samples will then be used for basic, clinical, and translational research with the goal of finding predictors of response to therapy and predictors of relapse that will lead to precision medicine strategies and new therapeutic targets that will improve the quality of life of patients with IBD.  

When fully enrolled, SPARC will follow 7,000 well-characterized (phenotyped) adult patients,  integrating their clinical data and self-reported outcome data and collecting serial biosamples over the course of their disease.

Samples can be used for basic, clinical, and translational research:

  • Comparative effectiveness research
  • Hypothesis / evidence generation
  • Drug targets and biomarkers discovery

Study Lead Co-Principal Investigators:

  • James D. Lewis, MD, MSCE – University of Pennsylvania, PA
  • Laura E. Raffals, MD, MS – Mayo Clinic, MN

Participating SPARC IBD sites:

  • Brigham & Women’s Hospital, MA
    Scott B. Snapper, MD, PhD
    Joshua R. Korzenik, MD

  • Cedars-Sinai Medical Center, CA
    Dermot McGovern, MD, PhD, FRCP(LON)

  • Mayo Clinic, MN
    Laura E. Raffals, MD, MS

  • University of Maryland, MD
    Raymond K. Cross, MD, MS

  • University of Michigan, MI
    Peter Higgins, MD, PhD

  • University of Pennsylvania, PA
    Meenakshi Bewtra, MD, MPH, PhD
    James D. Lewis, MD, MSCE

  • University of Pittsburgh, PA
    Richard H. Duerr, MD

  • University of Wisconsin, WI
    Sumona Saha, MD, MS
    Freddy Caldera, DO

For more information, contact Cecile Norris, CCRC, Research Program Manager.