Crohn’s & Colitis Glossary

Targeted Synthetic Small Molecules

Oral medications that help reduce inflammation by specifically targeting parts of the immune system.

Thiopurine methyltransferase (TPMT)

A blood test for the activity of an enzyme that helps in breaking down certain medications – azathioprine and 6MP – and to establish safety and proper dosing of these medications.

Toxic megacolon

A severe complication associated with ulcerative colitis that leads to rapid enlargement of the colon and requires immediate treatment and surgery. Symptoms include pain, distension or swelling of the abdomen, fever, rapid heart rate, constipation, and dehydration.

Translational research

A research approach that aims to move scientific discoveries into practice, to improve human health through the development of drugs, therapies, techniques, and medical devices.

Treat-to-target

An individualized strategy that defines a treatment target (like remission or low disease activity) and applies a strict regimen (for example, monthly visits and treatment adjustment) to reach that target.

Trigger Food

A food that can make your IBD symptoms worse – such as causing diarrhea, bloating, pain, or vomiting.