Chronic Abdominal Pain in IBD: Academic Request for Proposals

Letter of Intent deadline: July 22, 2021

Many IBD patients experience chronic abdominal pain, which can persist even if inflammation is under control. Chronic pain in IBD can dramatically impact quality of life of patients. Unfortunately, current treatments for pain management in IBD are inadequate. The development of new treatment modalities is a pressing priority, but progress has been limited by insufficient understanding of the biological causes of chronic abdominal pain in IBD. In order to address this critical unmet need, the Crohn’s & Colitis Foundation is excited to announce a Request for Proposals (RFP) to support research in this area. Proposals should focus on characterizing the clinical and biological heterogeneity among IBD patients suffering chronic pain, and on cellular and molecular mechanisms underlying this phenomenon. 

For detailed information regarding the program scope, eligibility, policies, and application instructions, click here to download the full RFP document. Proposed studies should align with the scope of the RFP (section 2), including:  

  • IBD patient-based studies to categorize phenotypic and endotypic heterogeneity of patients with chronic pain
  • Preclinical mechanistic studies in which hypotheses are derived from patient-based data and observations, to better understand the biological drivers of pain chronicity   
  • Experimental humanized in vitro and/or in vivo model-based preclinical studies to identify biological pathways and mechanisms of persistent visceral hypersensitivity 
  • Studies must integrate both patient-based profiling and experimental model-based mechanistic studies

Proposed budgets of up to $900,000 over three years will be considered. Academic investigators from around the world are eligible to submit a Letter of Intent by July 22, 2021. We do not anticipate that this RFP will be reissued in 2022.

For further information on the background, goals and priorities of this RFP, read the Foundation’s recent publication: Hurtado-Lorenzo, Honig, Weaver, Larkin & Heller. Chronic Abdominal Pain in IBD Research Initiative: Unraveling Biological Mechanisms and Patient Heterogeneity to Personalize Treatment and Improve Clinical Outcomes. Crohn's & Colitis 360, in press.

How to apply

Program information, LOI  and other application forms can be accessed and must be submitted through proposalCENTRAL.

  • Navigate to the Grant Opportunities tab (top right)
  • Filter by grant maker (select Crohn's & Colitis Foundation) to find the application link for Chronic Abdominal Pain in IBD RFP

Upcoming Letter of Intent deadline: July 22, 2021 

Questions? Contact Dr. Gerard Honig, Director of Research Innovation, at [email protected]