Methotrexate (MTX, Rhematrex, Mexate)

Dear @Name@,

Your doctor has discussed the following subject with you: methotrexate . Here is some additional information. Let us know if you have any questions regarding this information.

  • This medication belongs to a class of drugs called immunomodulators. It helps to reduce irritation and swelling (inflammation) in the intestines. It also decreases the long-term need for steroids. For that reason, it is sometimes referred to as a "steroid-sparing" drug. In some cases, this medication is used by itself. In other cases, this medication is used together with another medication to achieve better results.
  • Infrequently reported side effects include flu-like symptoms (nausea, vomiting, headache, fatigue, and diarrhea), mouth sores, and low white blood cell count. Less common side effects include scarring of the liver and lung inflammation. Some of the side effects can be prevented by adding folic acid (a vitamin).
  • Should be avoided by pregnant women. If you would like to become pregnant, this medication should be avoided by both men and women several months before pregnancy.
  • Blood tests should be performed frequently to check for medication effects on the bone marrow and liver.
  • Before taking this medication, let your doctor know about other medical conditions that you may have or other medications (even over-the-counter medications or alternative therapies) you may be taking.
  • The best way to control your disease is by taking your medication as directed. Even when you do not have any symptoms, it is very important to continue taking your medication to prevent your disease from becoming active again. Do not alter the amount of the medication or how frequently you take it on your own.
  • If you have any side effects or you continue to have symptoms, speak to your doctor immediately.


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