Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents with Crohn Disease
We will examine adolescents with newly diagnosed Crohn’s disease at baseline and one year later to evaluate the impact of Crohn’s disease inflammatory activity on bone marrow fat, bone mineral density, bone turnover markers, and to correlate with peripheral blood molecular and immune cell parameters.
In this longitudinal case-control study, we will evaluate bone marrow fat, areal and volumetric bone mineral density in adolescents with newly diagnosed Crohn’s disease versus healthy matched controls using magnetic resonance imaging (MRI), dual-energy x-ray absorptiometry (DXA), and peripheral quantitative computed tomography (pQCT). This study includes a baseline visit and a follow up visit one year later. Study participants will have the above imaging studies, bloodwork, and questionnaires.
Description of treatment or intervention (mechanism of action):
do imaging studies, bloodwork, and complete questionnaires.
This study has been designated as minimal risk. Study risks include: a very low dose of radiation from the DXA and pQCT; discomfort from the noise of the MRI; discomfort from completing questionnaires.