IBD Plexus: Publications

Doctor and patient looking at report together

IBD Plexus® is the largest data platform with biosamples in the IBD field. We are breaking down traditional barriers to data and scientific collaborations to generate high-impact research to advance the science of IBD. 

The data and biosamples collected from our research initiatives —SPARC IBDIBD Qorus, the Pediatric RISK Stratification study, and IBD Partners—drives the value of our exchange network. Use the list tool below to find peer-reviewed manuscripts, abstracts, and posters from leading experts across industry and academia.


SPARC IBD: Adult Prospective Research Study

SPARC IBD is a multicentered longitudinal study of adult IBD patients, which will collect and link clinical data, patient-reported outcome data, and serial biosamples through the course of the patients' disease. Learn more.


The Development and Initial Findings of A Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD)

Inflammatory Bowel Diseases. February 2022


Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility

Nature Genetics. August 2022


Patients With Stricturing or Penetrating Crohn’s Disease Phenotypes Report High Disease Burden and Treatment Needs

Inflammatory Bowel Diseases. July 2022.


Chicken or Egg, Mental Health Disorders in Inflammatory Bowel Disease: Does It Matter?

Gastroenterology: Editorial; April 2022


The Microbial Landscape of Ulcerative Colitis in Endoscopic Remission

Inflammatory Bowel Diseases, February 2022


The Development and Initial Findings of A Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease

Inflammatory Bowel Diseases, August 2021


Prevalence and factors associated with fecal urgency among patients with ulcerative colitis and Crohn’s disease in SPARC IBD

Crohn's & Colitis 360, July 2021


Fecal Incontinence in Inflammatory Bowel Disease

Crohn’s & Colitis 360, April 2021


The Microbial Landscape of Ulcerative Colitis in Remission.

Digestive Diseases Week (DDW); May 2022


Change in urgency among ulcerative colitis patients: Analyses from the SPARC IBD

Journal of Crohn's and Colitis, May 2021


A strategy to solve complexity of physician diagnosis using a mixture of Patient Reports and Provider Reports: A Case Study of Crohn’s Disease Phenotypes 

Journal of Crohn's and Colitis, May 2021


Prevalence of Fatigue among Crohn’s Disease and Ulcerative Colitis Patients: Analyses from SPARC IBD

Digestive Diseases Week (DDW); Virtual, May 2021


Patients with penetrating and/or stricturing Crohn’s disease have a higher reported prevalence of active intestinal and extra-intestinal symptoms, surgeries and need for biologics: Analysis of the study of a prospective adult research cohort with IBD

Digestive Diseases Week (DDW); Virtual, May 2021


Fecal Incontinence in Inflammatory Bowel Disease

May 2020


Factors Associated with Fecal Urgency in Inflammatory Bowel Disease Patients: A Cross-Sectional Study from SPARC IBD

Inflammatory Bowel Diseases, January 2020


Creation of a Prospective, Longitudinal Adult Inflammatory Bowel Disease Cohort Combining High-Resolution Phenotyping with Biosample Collection to Facilitate Precision Medicine: SPARC IBD

Inflammatory Bowel Diseases, January 2020


Real World Prevalence of Bowel Movement Urgency – A Snapshot of Symptom Experience Reported by Patients with Ulcerative Colitis Participating in SPARC IBD

Inflammatory Bowel Diseases, January 2020

IBD Qorus

IBD Qorus is designed to drive improved care and health outcomes for patients living with IBD. This first-ever adult IBD learning health system leverages the power of a collaborative improvement network. It brings together providers and patients across the United States to focus on improving how care is delivered in order to produce outcomes-driven results. Learn more.


Fostering Collaboration Through Creation of an IBD Learning Health System

American Journal of GastroenterologyMarch 2017

Abstracts /posters

Top Goals and Concerns Reported by Individuals with Inflammatory Bowel Disease at Outpatient Gastroenterology Clinic Visits

Gastroenterology, February 2020

Pediatric RISK Stratification Study

The Foundation launched its Pediatric RISK Stratification Study to document and examine Crohn’s disease in children in hopes of finding a diagnostic predictor of which children will later develop serious complications requiring surgery. Learn more about the RISK study.


Profiling non-coding RNA levels with clinical classifiers in pediatric Crohn’s disease

BMC Medical Genomics, July 2021


Association of Baseline Luminal Narrowing With Ileal Microbial Shifts and Gene Expression Programs and Subsequent Transmural Healing in Pediatric Crohn Disease

Inflammatory Bowel Diseases, January 2021


Mucosal Inflammatory and Wound Healing Gene Programs Reveal Targets for Stricturing Behavior in Pediatric Crohn’s Disease

Journal of Crohn's and Colitis, August 2020


Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy

Cell, September 2019


Variation in care in the management of children with Crohn’s disease: data from a multicenter inception cohort study.

Inflammatory Bowel Diseases, June 2019


Blood-Derived DNA methylation signatures of Crohn’s disease largely a consequence of inflammation.

Gastroenterology, June 2019


Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony Stimulating Factor Signaling in Pediatric Crohn Disease

Inflammatory Bowel Diseases, February 2019


The Effect of Early-Life Environmental Exposures on Disease Phenotype and Clinical Course of Crohn’s Disease in Children.

American Journal of Gastroenterology, October 2018


Association Between Plasma Level of Collagen Type III alpha 1 Chain and Development of Strictures in Pediatric Patients With Crohn's Disease

Clinical Gastroenterology and Hepatology, September 2018


Evolution of Pediatric Inflammatory Bowel Disease Unclassified (IBD-U): Incorporated With Serological and Gene Expression Profiles.

Inflammatory Bowel Diseases, May 2018


Genetic variants and pathways implicated in a pediatric inflammatory bowel disease cohort.

Genes & Immunity, March 2018


NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease

Mucosal Immunology, March 2018


Clinical and Genomic Correlates of Neutrophil Reactive Oxygen Species Production in Pediatric Patients with Crohn's Disease

Gastroenterology, February 2018


Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease

Inflammatory Bowel Diseases, January 2018


Transcriptional risk scores link GWAS to eQTLs and predict complications in Crohn's disease

Nature Genetics, October 2017


Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-only Crohn's Disease in Treatment-naïve Pediatric Patients.

Gastroenterology, May 2017


Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study

Lancet, April 2017


Improved integrative framework combining association data with gene expression features to prioritize Crohn's disease genes

Human Molecular Genetics, July 2015


Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping.

PLoS One, June 2015


Pediatric Crohn disease patients exhibit specific  ileal transcriptome and microbiome signature

Journal of Clinical Investigation, August 2014


Utility of neutrophil Fcγ receptor I (CD64) index as a biomarker for mucosal inflammation in pediatric Crohn's disease.

Inflammatory Bowel Diseases, June 2014


The treatment-naïve microbiome in new-onset Crohn’s disease.  

Cell Host & Microbe, March 2014


Increased Effectiveness of Early Therapy with Anti-Tumor Necrosis Factor-α vs an Immunomodulator in Children With Crohn's Disease.

Gastroenterology, February 2014

IBD Partners: Online Patient Survey Study

IBD Partners is a patient-powered research network and an online registry with more than 15,000 adult IBD patients from across the country. There is a parallel registry of over 900 kids and teens.

Click here to browse published studies from IBD Partners.