IBD Plexus: Publications

Doctor and patient looking at report together

IBD Plexus® is the largest data platform with biosamples in the IBD field. We are breaking down traditional barriers to data and scientific collaborations to generate high-impact research to advance the science of IBD.

 

The data and biosamples collected from our research initiatives —SPARC IBDIBD Qorus, the Pediatric RISK Stratification study, and IBD Partners—drives the value of our exchange network. Use the list tool below to find peer-reviewed manuscripts, abstracts,

and posters from leading experts across industry and academia.

 

SPARC IBD: Adult Prospective Research Study

SPARC IBD is a multicentered longitudinal study of adult IBD patients, which will collect and link clinical data, patient-reported outcome data, and serial biosamples through the course of the patients' disease. Learn more.

Manuscripts

Extra-Intestinal Manifestations of Inflammatory Bowel Disease are Associated with Increased Biologic Cycling

Crohn's & Colitis 360, October 2023

 

Dynamics of the Gut Mycobiome in Patients with Ulcerative Colitis

Clinical Gastroenterology and Hepatology, October 2023

 

Assessing Progression of Biologic Therapies Based on Smoking Status in Patients With Crohn’s Disease

Inflammatory Bowel Diseases, July 2023

 

Yield of Serial Testing for Tuberculosis Exposure in Patients With Inflammatory Bowel Diseases: One Test is Not Enough

Clinical Gastroenterology and Hepatology, June 2023

 

Alterations in the Fungal Microbiome in Ulcerative Colitis

Inflammatory Bowel Diseases, May 2023

 

Comparing Patient Reported Outcomes among Anti-TNF Experienced Patients with Ulcerative Colitis Initiating Vedolizumab versus Tofacitinib

Crohn's & Colitis 360, May 2023

 

Utilization of Treat-to-Target Monitoring Colonoscopy after Treatment Initiation in the US-Based Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD)

The American Journal of Gastroenterology, April 2023

 

Second-Line Biologic Therapy Following Tumor Necrosis Factor Antagonist Failure: A Real-World Propensity Score-Weighted Analysis

Clinical Gastroenterology and Hepatology, February 2023

 

Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease

Nature Medicine, February 2023

 

Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility

Nature Genetics, August 2022

 

Patients With Stricturing or Penetrating Crohn’s Disease Phenotypes Report High Disease Burden and Treatment Needs

Inflammatory Bowel Diseases, July 2022

 

Chicken or Egg, Mental Health Disorders in Inflammatory Bowel Disease: Does It Matter?

Gastroenterology: Editorial, April 2022

 

The Microbial Landscape of Ulcerative Colitis in Endoscopic Remission

Inflammatory Bowel Diseases, February 2022

 

The Development and Initial Findings of A Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease

Inflammatory Bowel Diseases, August 2021

 

Prevalence and factors associated with fecal urgency among patients with ulcerative colitis and Crohn’s disease in SPARC IBD

Crohn's & Colitis 360, July 2021

 

Fecal Incontinence in Inflammatory Bowel Disease

Crohn’s & Colitis 360, April 2021


Abstracts/posters

Interpretable histopathology-based prediction of disease relevant features in Inflammatory Bowel Disease biopsies using weakly-supervised deep learning

Medical Imaging with Deep Learning Conference, July 2023

 

Uncovering genetic mechanisms of inflammatory bowel disease through DNA-RNA integration analyses of the inflamed colon tissue

European Human Genetics Conference, June 2023

 

Blood-based DNA Methylation Biomarkers to Distinguish Irritable Bowel Syndrome, Inflammatory Bowel Disease and Celiac Disease

Digestive Diseases Week (DDW), May 2023

 

Sex-based Differences in Clinical and Endoscopic Outcomes Among Patients with Inflammatory Bowel Diseases

Digestive Diseases Week (DDW), May 2023

 

Sex-based Differences in Drug Durability Among Patients with Inflammatory Bowel Diseases

Digestive Diseases Week (DDW), May 2023

 

Correlation Between Serum and Fecal Biomarkers and Patient Reported Outcomes in Patients with Crohn’s Disease and Ulcerative Colitis

Digestive Diseases Week (DDW), May 2023

 

Healthcare resource utilization 18-Month Follow-up of Crohn’s Disease Patients Stratified by Severity 

Digestive Diseases Week (DDW), May 2023

 

The CCR9/CCL25 axis is specific to the ileum and is correlated with stricturing disease

Journal of Crohn's and Colitis, January 2023

 

Deep characterization of IL-23 pathway in different gut segments and associated plasma biomarkers in inflammatory bowel disease

Journal of Crohn's and Colitis, January 2023

 

Predicting disease relevant features in Crohn’s Disease and Ulcerative Colitis from Haematoxylin & Eosin stained whole slide images using self-supervised deep learning

Journal of Crohn's and Colitis, January 2023

 

Colonic rather than ileal expression of ITGA4/ITGB7 correlates with local intestinal inflammation in IBD

Journal of Crohn's and Colitis, January 2023

 

Clinical significance of plasma interleukin-22 as a biomarker of inflammation in patients with Crohn’s disease and ulcerative colitis

Journal of Crohn's and Colitis, January 2023

 

Sex-Based Differences in Drug Durability Among Patients with Inflammatory Bowel Disease

Inflammatory Bowel Diseases, January 2023

 

Predictors of Developing Multiple Extra-Intestinal Manifestations of Inflammatory Bowel Disease

Inflammatory Bowel Diseases, January 2023

 

Association Between Antibiotic Use and Inflammatory Bowel Disease Outcomes

Inflammatory Bowel Diseases, January 2023

 

Gut Microbial Metabolism of 5-ASA is Prospectively Associated with Treatment Failure in Patients with IBD

Inflammatory Bowel Diseases, January 2023

 

Using R to Advance Patient-Centric Research in the Study of a Prospective Adult Research Cohort

Inflammatory Bowel Diseases, January 2023

 

Yield of Serial Testing for Tuberculosis Exposure in the Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease

Inflammatory Bowel Diseases, January 2023

 

Characteristics, Medication and Healthcare Utilization of Crohn’s Disease Patients Stratified by Short-CDAI Status: Descriptive Results From the IBD PLEXUS and IQVIA Linked Dataset

The American Journal of Gastroenterology, October 2022

 

The Microbial Landscape of Ulcerative Colitis in Remission.

Digestive Diseases Week (DDW); May 2022

 

Risks of Development of COVID-19 among Patients with Inflammatory Bowel Disease

Journal of Crohn's and Colitis, January 2022

 

Change in urgency among ulcerative colitis patients: Analyses from the SPARC IBD

Journal of Crohn's and Colitis, May 2021

 

A strategy to solve complexity of physician diagnosis using a mixture of Patient Reports and Provider Reports: A Case Study of Crohn’s Disease Phenotypes 

Journal of Crohn's and Colitis, May 2021

 

Prevalence of Fatigue among Crohn’s Disease and Ulcerative Colitis Patients: Analyses from SPARC IBD

Digestive Diseases Week (DDW); Virtual, May 2021

 

Patients with penetrating and/or stricturing Crohn’s disease have a higher reported prevalence of active intestinal and extra-intestinal symptoms, surgeries and need for biologics: Analysis of the study of a prospective adult research cohort with IBD

Digestive Diseases Week (DDW); Virtual, May 2021

 

Fecal Incontinence in Inflammatory Bowel Disease

May 2020

 

Factors Associated with Fecal Urgency in Inflammatory Bowel Disease Patients: A Cross-Sectional Study from SPARC IBD

Inflammatory Bowel Diseases, January 2020

 

Creation of a Prospective, Longitudinal Adult Inflammatory Bowel Disease Cohort Combining High-Resolution Phenotyping with Biosample Collection to Facilitate Precision Medicine: SPARC IBD

Inflammatory Bowel Diseases, January 2020

 

Real World Prevalence of Bowel Movement Urgency – A Snapshot of Symptom Experience Reported by Patients with Ulcerative Colitis Participating in SPARC IBD

Inflammatory Bowel Diseases, January 2020

IBD Qorus

IBD Qorus is designed to drive improved care and health outcomes for patients living with IBD. This first-ever adult IBD learning health system leverages the power of a collaborative improvement network. It brings together providers and patients across the United States to focus on improving how care is delivered in order to produce outcomes-driven results. Learn more.

Manuscripts

Fostering Collaboration Through Creation of an IBD Learning Health System

American Journal of GastroenterologyMarch 2017


Abstracts /posters

Top Goals and Concerns Reported by Individuals with Inflammatory Bowel Disease at Outpatient Gastroenterology Clinic Visits

Gastroenterology, February 2020

Pediatric RISK Stratification Study

The Foundation launched its Pediatric RISK Stratification Study to document and examine Crohn’s disease in children in hopes of finding a diagnostic predictor of which children will later develop serious complications requiring surgery. Learn more about the RISK study.

Publications

Progression of Pediatric Crohn’s Disease is Associated with Anti-TNF Timing and BMI Z-Score Normalization

Clinical Gastroenterology and Hepatology, October 2023

 

The Clinical Response of Upadacitinib and Risankizumab Is Associated With Reduced Inflammatory Bowel Disease Anti-TNF-α Inadequate Response Mechanisms

Inflammatory Bowel Diseases, May 2023

 

Mucosal microbiome is predictive of pediatric Crohn’s disease across geographic regions in North America

F1000Research, January 2023

 

Identifying metabolic shifts in Crohn's disease using 'omics-driven contextualized computational metabolic network models

Nature Genetics, January 2023

 

Biopsy and blood-based molecular biomarker of inflammation in IBD
Gut, September 2022

 

Profiling non-coding RNA levels with clinical classifiers in pediatric Crohn’s disease

BMC Medical Genomics, July 2021

 

Association of Baseline Luminal Narrowing With Ileal Microbial Shifts and Gene Expression Programs and Subsequent Transmural Healing in Pediatric Crohn Disease

Inflammatory Bowel Diseases, January 2021

 

Mucosal Inflammatory and Wound Healing Gene Programs Reveal Targets for Stricturing Behavior in Pediatric Crohn’s Disease

Journal of Crohn's and Colitis, August 2020

 

Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy

Cell, September 2019

 

Variation in care in the management of children with Crohn’s disease: data from a multicenter inception cohort study

Inflammatory Bowel Diseases, June 2019

 

Blood-Derived DNA methylation signatures of Crohn’s disease largely a consequence of inflammation

Gastroenterology, June 2019

 

Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony Stimulating Factor Signaling in Pediatric Crohn Disease

Inflammatory Bowel Diseases, February 2019

 

The Effect of Early-Life Environmental Exposures on Disease Phenotype and Clinical Course of Crohn’s Disease in Children

American Journal of Gastroenterology, October 2018

 

Association Between Plasma Level of Collagen Type III alpha 1 Chain and Development of Strictures in Pediatric Patients With Crohn's Disease

Clinical Gastroenterology and Hepatology, September 2018

 

Evolution of Pediatric Inflammatory Bowel Disease Unclassified (IBD-U): Incorporated With Serological and Gene Expression Profiles

Inflammatory Bowel Diseases, May 2018

 

Genetic variants and pathways implicated in a pediatric inflammatory bowel disease cohort

Genes & Immunity, March 2018

 

NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease

Mucosal Immunology, March 2018

 

Clinical and Genomic Correlates of Neutrophil Reactive Oxygen Species Production in Pediatric Patients with Crohn's Disease

Gastroenterology, February 2018

 

Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease

Inflammatory Bowel Diseases, January 2018

 

Transcriptional risk scores link GWAS to eQTLs and predict complications in Crohn's disease

Nature Genetics, October 2017

 

Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-only Crohn's Disease in Treatment-naïve Pediatric Patients

Gastroenterology, May 2017

 

Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study

Lancet, April 2017

 

Improved integrative framework combining association data with gene expression features to prioritize Crohn's disease genes

Human Molecular Genetics, July 2015

 

Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping

PLoS One, June 2015

 

Pediatric Crohn disease patients exhibit specific  ileal transcriptome and microbiome signature

Journal of Clinical Investigation, August 2014

 

Utility of neutrophil Fcγ receptor I (CD64) index as a biomarker for mucosal inflammation in pediatric Crohn's disease

Inflammatory Bowel Diseases, June 2014

 

The treatment-naïve microbiome in new-onset Crohn’s disease

Cell Host & Microbe, March 2014

 

Increased Effectiveness of Early Therapy with Anti-Tumor Necrosis Factor-α vs an Immunomodulator in Children With Crohn's Disease

Gastroenterology, February 2014

IBD Partners: Online Patient Survey Study

IBD Partners is a patient-powered research network and an online registry with more than 15,000 adult IBD patients from across the country. There is a parallel registry of over 900 kids and teens.

Click here to browse published studies from IBD Partners.