What is IBD Plexus?

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Data depth fuels research excellence.

Despite the expanding IBD treatment landscape, challenges like non-response, loss of response, and adverse reactions persist. Better data is crucial for improving patient outcomes. Our approach provides researchers with unparalleled data for a holistic understanding that accelerates discoveries.



Invested in generating adult and pediatric molecular data


Invested in generating adult and pediatric molecular data



Patients with whole exome sequencing

RNA-seq data sets from intestinal biopsies


RNA-seq data sets from intestinal biopsies

Proteomics datasets from plasma


Proteomics datasets from plasma


The IBD Plexus difference.


Patient journeys are at the forefront

A comprehensive 360-degree view of the patient includes medication journey, changes in clinical scores, and molecular data.


Integrated, diverse, and research-ready

Data aggregated from 90+ participating sites undergoes rigorous standardization and is ready to address questions along the entire drug development continuum.


Precompetitive initiatives accelerate progress

By promoting knowledge-sharing and shared infrastructure, we bring together industry leaders to tackle the most important questions in IBD research from disease progression to fibrostenosis to the use of RWE for regulatory decisions.

The IBD Plexus Experience


Discover the versatility of a united, comprehensive dataset.

IBD Plexus offers a 360-view of patients, allowing for a holistic understanding of their journeys. This richly comprehensive outlook supports research from drug development to treatment strategies, driving advancements in IBD.

Patient-Reported Outcomes

We believe the patient is the most underutilized research resource. We listen to patients to learn about their:


  • Fatigue
  • Pain
  • Fecal urgency
  • Frequency and quality of bowel movements
  • Quality of life
Clinical Data

Detailed, disease-specific data is critical to fully understanding the disease journey and therapeutic effectiveness. We collect thorough data on:


  • Disease severity scores such as PGA and CDAI
  • Relevant lab scores such as fecal calprotectin and C-reactive protein
  • Disease phenotypes and location
  • Medication journey
  • Extraintestinal manifestations
Endoscopic Data

Endoscopic data is gathered from procedures and provides detailed information about the condition of the gastrointestinal tract. During endoscopy, the physician records all components of the simple endoscopic score for Crohn’s disease and the modified Mayo endoscopic score for ulcerative colitis. We also calculate the complete scores.

Biosamples + Molecular Data

We collect plasma, stool, and intestinal tissue from some patients enrolled in IBD Plexus. While these are available for researchers, we have also generated the following biosample-derived data:


  • Intestinal tissue (digitized FFPE slides and transcriptomics)
  • Blood (isolated PMBCs, plasma proteomics, genotyping array, and whole exome sequencing)
  • Stool (metagenomic sequencing)
Electronic Medical Records

In addition to the unstructured information found within the EMR, we also have extracted structured information, including:

  • Patient diagnoses
  • Patient history
  • Patient problems
  • Medication usage
  • Lab test results

These de-identified data elements provide a rich and multifaceted view of IBD and support a wide range of research and precision medicine initiatives.

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Our principles safeguard IBD data and patient interests that drive successful outcomes.


The Crohn's and Colitis Foundation is dedicated to curing Crohn's disease and ulcerative colitis. Our research foundation is built on the belief that addressing patients’ unmet needs sparks revolutionary breakthroughs and significantly improved outcomes.




Accelerate your research with IBD Plexus.

Hypothesize, analyze, and utilize the world’s largest dataset to revolutionize precision medicine the way you should it could be.