­­We will examine adolescents with newly diagnosed Crohn’s disease at baseline and one year later to evaluate the impact of Crohn’s disease inflammatory activity on bone marrow fat, bone mineral density, bone turnover markers, and to correlate with peripheral blood molecular and immune cell parameters.

The PLANET Study aims to determine the impact of microplastics on intestinal inflammation and the gut microbiome in order to understand the role of this pollutant on the risk of developing IBD as well as other diseases. With this information, the study team hopes to characterize better the role of environmental pollutants on IBD and develop novel strategies towards prevention.

The hypothesis of this study is that the appropriate time of day of administration of oral, once-daily 5-ASA therapy in alignment with the participant’s circadian rhythms will improve subclinical inflammation and microbial structure/function and increase mucosal 5-ASA levels.

To understand important effects of inflammatory bowel disease and its treatments on male reproductive health and fertility

To investigate if circadian malalignment (unusual sleeping patterns), such as night shifts (sleeping during the day and being awake during the night time), worsens the inflammation of the gut.