IBD SIRQC (IBD Surgical Innovation, Research, and Quality Collaborative) is the Foundation’s first-ever surgical research initiative. SIRQC will enroll adults with Crohn’s disease or ulcerative colitis preparing to have GI surgery and will follow them through their surgery and beyond. This cohort study will track long-term surgery outcomes and our understanding of the impact of surgery on IBD including post-procedure complications and disease recurrence.


SIRQC also aims to advance precision medicine by identifying factors that can be used to predict who is most likely to remain healthy after surgery and who will need further intervention and treatment. SIRQC is looking to enroll 5,000 patients at 9 sites in the United States and Canada.


Participants in SIRQC will undergo surgery with their participating GI surgeon and give permission to share data and biosamples for analysis.

Study Lead Co-Principal Investigators

  • Stefan Holubar, MD, MS – Cleveland Clinic, OH
  • Samuel Eisenstein, MD – UC San Diego, CA

Participating IBD SIRQC Sites

Baylor Scott & White Health, TX

  • Sarah Stringfield, MD

Cedars-Sinai Medical Center, CA

  • Karen Zaghiyan, MD

Cleveland Clinic, OH

  • Stefan Holubar, MD

University of Chicago, IL

  • Kinga Olortegui, MD

University of California San Diego, CA

  • Sam Eisenstein, MD

Mount Sinai Hospital Toronto, ON

  • Anthony de Buck, MD

University of North Carolina at Chapel Hill, NC

  • Muneera Kapadia, MD

Cleveland Clinic Florida, FL

  • Giovanna da Silva, MD

Spectrum Health, MI

  • James Ogilvie, Jr., MD